Imputation · powered by Responder Atlas
Structure to indication signal, instantly.
Paste a SMILES string. Imputation queries Responder Atlas — our platform built on public pharmacogenomic data — and returns a ranked signal across 17 cancer tissue types with a confidence tier from chemical similarity to the training set. No account needed.
Sample result — gefitinib
This is an illustrative sample so you can see the format. Submit a SMILES above to get your own prediction. The values below come from our committed gefitinib report — they are not tied to anything you've typed.
Confidence & provenance
elevatedBasis: SMILES imputedModel: v0.3
- Max Tanimoto
- 1.00
- Nearest training drug
- gefitinib
- Neighbours ≥ 0.5
- 5
This compound is not in the training set — signal is imputed from chemical structure.
chemistry-similarity tier (max ECFP4 Tanimoto to v0.3 training set): elevated >=0.5 (committed node-rank rho ~0.62, 62.5% reach rho>0.5); moderate 0.4-0.5 (rho ~0.50, 50%); exploratory <0.4 (rho ~0.30, ~18%). Estimated, not guaranteed (committed outlier: doxorubicin tanimoto 1.0 yet rho 0.46).
Ranked indications
6 indications · server-ranked
- 01EsophaguselevatedPredicted viability change+44.2%
reduces viability — predicted cell killing
Selectivity vs. this drug's average+62%more responsive than this drug's own average
- 02Upper AerodigestiveelevatedPredicted viability change+32.6%
reduces viability — predicted cell killing
Selectivity vs. this drug's average+34%more responsive than this drug's own average
- 03Urinary TractelevatedPredicted viability change+30.5%
reduces viability — predicted cell killing
Selectivity vs. this drug's average+30%more responsive than this drug's own average
- 04PancreaselevatedPredicted viability change+18.7%
reduces viability — predicted cell killing
Selectivity vs. this drug's average+11%more responsive than this drug's own average
- 05UteruselevatedPredicted viability change+17.5%
reduces viability — predicted cell killing
Selectivity vs. this drug's average+10%more responsive than this drug's own average
- 06OvaryelevatedPredicted viability change+14.8%
reduces viability — predicted cell killing
Selectivity vs. this drug's average+6%more responsive than this drug's own average
Two different things. Predicted viability change is the absolute effect — whether the drug is predicted to reduce viability (kill; bar right of zero) or increase it (proliferate; bar left). Selectivity is how that indication compares to this drug's own average across all indications (bar right = more responsive). Both bars diverge around a zero line.
Preview shows the top 6 of 17 indications. A real submission returns the full ranked list.